Seeing any of the following behavior when interacting with PDF documents within SharePoint?
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The document could
not be opened for editing. A Windows Sharepoint Services compatible
application could not be found to edit the document.
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There was an error
opening this document. The file cannot be found.
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Missing/blank icon for PDF documents
Add this line to one-liner to your DOCICON.XML document (C:\Program Files\Common Files\Microsoft Shared\web server extensions\12\TEMPLATE\XML):
<Mapping Key="pdf" Value="pdf.gif" OpenControl="SharePoint.OpenDocuments"/>
And put the corresponding pdf.gif image in the SharePoint IMAGES directory (C:\Program Files\Common Files\Microsoft Shared\web server extensions\12\TEMPLATE\IMAGES).
If users are annoyed by the in-browser method with which PDF documents are opened, that setting must be changed via the Adobe Reader application itself - Edit > Preferences > Internet, uncheck the 'Display PDF in browser' box.